領先全球！揭71型腸病毒滅人體細胞致病機轉

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領先全球！揭71型腸病毒滅人體細胞致病機轉
更新日期:2011/01/21 18:05 71型腸病毒致病研究有重大突破！歷經三年，台大醫學院楊泮池院長率領研究團隊，揪出腸病毒滅殺並操控人體細胞機制，同時投入研發阻抑制劑，可延緩細胞病變並減少病毒產生達千倍以上，預計接下來進行動物與人體試驗，可望在一到兩年完成。這項研究獲得國際高度矚目，獲刊在微生物醫學領域首席期刊「細胞、宿主與微生物」上，被視為將來抗病毒治療的重要方向。(陳奕華報導)


腸病毒高傳染率、高重症率，嚴重威脅兒童健康，讓家長頭痛不已，尤其以71型腸病毒影響最大，嚴重可能引起腦膜炎、癱瘓、心肺衰竭甚至致死。歷經三年，國科會支持的跨領域研究團隊，領先全球，揭開腸病毒感染關鍵機制，台大醫學院院長楊泮池解釋，病毒非常聰明，變異性高，研究發現，71型腸病毒入侵人體後，會「擒賊先擒王」，操控調控細胞蛋白的微核糖核酸-141（microRNA-141），讓它開始製作病毒的蛋白，直到細胞死亡。


「它很聰明去控制Leader，控制連長，去控制整個細胞蛋白的合成，蛋白合成宿主沒有做自己的，就聽命於病毒的，去做病毒，宿主細胞受不了，就死掉了，死掉後病毒就跑出來，去感染其他細胞，這是它很成功造成人感染、傷害的機制。」


研究團隊突破性揭開71型腸病毒致病機轉，已經獲得美國暫時性專利以及世界專利合作條約通過，目前在台灣與美國正式專利申請中，研究團隊進一步研發可阻斷宿主細胞製作病毒的抑制劑，避免感染後造成二次傷害，研究發現，可降低病毒繁殖速度達一千倍，預計未來一到兩年進行動物、人體試驗，希望未來可有效治療腸病毒，同時擴及應用於致病機轉相同的小兒痲痺病毒、克沙奇病毒等。

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