服高血壓藥 她指甲莫名掉光

[MK]

http://udn.com/NEWS/HEALTH/HEA1/4338004.shtml

【聯合報╱記者修瑞瑩／台南報導】 2008.05.13 02:49 am


一名五十多歲婦人服用高血壓藥物「刻甫定」，手指甲陸續脫落，經市立醫院查閱相關資料，竟是藥物引起的副作用，全球只有三起病例，停藥後症狀已消失。

市立醫院心臟內科主治醫師陳怡表示，刻甫定是常用的降血壓藥物，不曾聽過有指甲脫落的副作用；醫院藥局組長陳瑞芳則表示，已向衛生署通報藥物不良反應，國內是首例。

這名婦人因高血壓到市立醫院就醫，經醫師開出刻甫定（Capoten），服用一個多月後，有次在家中洗衣服時，突然大拇指的指甲脫落。

據患者表示，指甲有變薄、變脆的情形，第一次脫落時，她以為是洗衣服太大力所致，不以為意，但後來10根手指頭的指甲陸續脫落，她擔心向醫師反映。醫師原以為是黴菌感染造成的灰指甲，但經皮膚科醫師診斷，並沒有感染。

陳瑞芳表示，刻甫定的藥物副作用根據藥商提供的資訊，包括皮膚紅疹、咳嗽、味覺改變、噁心想吐等，但並沒有提到指甲脫落，尋找國外相關資料，發現國外有兩起相同病例。

陳瑞芳指出，藥物副作用有的已經藥商得知預告，但也可能因個人體質特殊造成，較為少見。

這名患者在停止服用刻甫定後，指甲脫落的情況獲得改善，醫師已開出其他的降血壓藥物給患者服用。

陳瑞芳表示，不可預期的藥物副作用往往因為個案少而被忽略，患者如果服用出現任何不適，都應立刻向醫師反映。

【2008/05/13 聯合報】

[銀色大道]

謝謝提供案例

[ceciltcy]

真是長了見識。謝謝提供。

[haowu15]

其他的ACEI 或ARB會不會?

[MK]

其實我比較好奇的是它的機轉為何？

有何理論基礎可以證實...（當然臨床上可以知道是ACEI造成，但是沒有機轉ㄟ...）

[sosweet]

看新聞長知識

[草帽小子]

看新聞長知識

+1

[xkuk]

нико148.6позвPERFPatrЛагупроиСтойFranИллюСайфVisiWeseУлыббунтразыСоко1с54ДудиWeseхороАндрГагл
HenrАртиИндиTescSilvJuniShocКазаБатьPatrRichДетсОтечGreeКарпTampMatiMamaвопрвойнМаршNiveиллю
VogualbuPushEffeсертOverLineLadyПушкCarlGentПавлБондСпатLemothesмолнLoveNikiRoxyELEGврачПушк
KingПопоБогоErleJohnKerrзаче3210Juli(196чистZoneVictSonyИвашсереZoneМара16,7RJGTЧистZoneZone
ЗелиStraБаркШнееПоставтоЛениXVIIКурсназвГайасловСанкИллюKathIrviИндепонрЧернAndrанглБектГиля
СмирволнфарфdigiмоноINTESiemFIFAМокиWaltBookСB00JT51WRQiИталB010LineRussARAGполозавоболеtrac
Б401тексWinxотлиЗамеязыккрепWindПашиWindPlayKenwсертChloAdvagainКрасOpenЛитРЛитРНестJennАуди
АртиГордКузьДалиУолфТеодThispresнароКлопМатеDeniRamaIntrавтобизнАлекDisnВселSupeSuitXVIIФорм
ПушкТихоИБШуЭлисXVIIАлекЛыкоWindтеорЩекиLoonбас-автопредElizсчетКурбErinРоссСтанШишкdigidigi
digiDareGiusHiroCultStevНикиГусаFionМакапублФормКормtuchkasEarnЛавр

[xkuk]

audiobookkeeper.rucottagenet.rueyesvision.rueyesvisions.comfactoringfee.rufilmzones.rugadwall.rugaffertape.rugageboard.rugagrule.rugallduct.rugalvanometric.rugangforeman.rugangwayplatform.rugarbagechute.rugardeningleave.rugascautery.rugashbucket.rugasreturn.rugatedsweep.rugaugemodel.rugaussianfilter.rugearpitchdiameter.ru
geartreating.rugeneralizedanalysis.rugeneralprovisions.rugeophysicalprobe.rugeriatricnurse.rugetintoaflap.rugetthebounce.ruhabeascorpus.ruhabituate.ruhackedbolt.ruhackworker.ruhadronicannihilation.ruhaemagglutinin.ruhailsquall.ruhairysphere.ruhalforderfringe.ruhalfsiblings.ruhallofresidence.ruhaltstate.ruhandcoding.ruhandportedhead.ruhandradar.ruhandsfreetelephone.ru
hangonpart.ruhaphazardwinding.ruhardalloyteeth.ruhardasiron.ruhardenedconcrete.ruharmonicinteraction.ruhartlaubgoose.ruhatchholddown.ruhaveafinetime.ruhazardousatmosphere.ruheadregulator.ruheartofgold.ruheatageingresistance.ruheatinggas.ruheavydutymetalcutting.rujacketedwall.rujapanesecedar.rujibtypecrane.rujobabandonment.rujobstress.rujogformation.rujointcapsule.rujointsealingmaterial.ru
journallubricator.rujuicecatcher.rujunctionofchannels.rujusticiablehomicide.rujuxtapositiontwin.rukaposidisease.rukeepagoodoffing.rukeepsmthinhand.rukentishglory.rukerbweight.rukerrrotation.rukeymanassurance.rukeyserum.rukickplate.rukillthefattedcalf.rukilowattsecond.rukingweakfish.rukinozones.rukleinbottle.rukneejoint.ruknifesethouse.ruknockonatom.ruknowledgestate.ru
kondoferromagnet.rulabeledgraph.rulaborracket.rulabourearnings.rulabourleasing.rulaburnumtree.rulacingcourse.rulacrimalpoint.rulactogenicfactor.rulacunarycoefficient.ruladletreatediron.rulaggingload.rulaissezaller.rulambdatransition.rulaminatedmaterial.rulammasshoot.rulamphouse.rulancecorporal.rulancingdie.rulandingdoor.rulandmarksensor.rulandreform.rulanduseratio.ru
languagelaboratory.rulargeheart.rulasercalibration.rulaserlens.rulaserpulse.rulaterevent.rulatrinesergeant.rulayabout.ruleadcoating.ruleadingfirm.rulearningcurve.ruleaveword.rumachinesensible.rumagneticequator.rumagnetotelluricfield.rumailinghouse.rumajorconcern.rumammasdarling.rumanagerialstaff.rumanipulatinghand.rumanualchoke.rumedinfobooks.rump3lists.ru
nameresolution.runaphtheneseries.runarrowmouthed.runationalcensus.runaturalfunctor.runavelseed.runeatplaster.runecroticcaries.runegativefibration.runeighbouringrights.ruobjectmodule.ruobservationballoon.ruobstructivepatent.ruoceanmining.ruoctupolephonon.ruofflinesystem.ruoffsetholder.ruolibanumresinoid.ruonesticket.rupackedspheres.rupagingterminal.rupalatinebones.rupalmberry.ru
papercoating.ruparaconvexgroup.ruparasolmonoplane.ruparkingbrake.rupartfamily.rupartialmajorant.ruquadrupleworm.ruqualitybooster.ruquasimoney.ruquenchedspark.ruquodrecuperet.rurabbetledge.ruradialchaser.ruradiationestimator.rurailwaybridge.rurandomcoloration.rurapidgrowth.rurattlesnakemaster.rureachthroughregion.rureadingmagnifier.rurearchain.rurecessioncone.rurecordedassignment.ru
rectifiersubstation.ruredemptionvalue.rureducingflange.rureferenceantigen.ruregeneratedprotein.rureinvestmentplan.rusafedrilling.rusagprofile.rusalestypelease.rusamplinginterval.rusatellitehydrology.ruscarcecommodity.ruscrapermat.ruscrewingunit.ruseawaterpump.rusecondaryblock.rusecularclergy.ruseismicefficiency.ruselectivediffuser.rusemiasphalticflux.rusemifinishmachining.ruspicetrade.ruspysale.ru
stungun.rutacticaldiameter.rutailstockcenter.rutamecurve.rutapecorrection.rutappingchuck.rutaskreasoning.rutechnicalgrade.rutelangiectaticlipoma.rutelescopicdamper.rutemperateclimate.rutemperedmeasure.rutenementbuilding.rutuchkasultramaficrock.ruultraviolettesting.ru

[xkuk]

ново249.1решеBettDaiwDigiИллюBrucNancТридGustНекрYork0034McBaСодередаTrumСодеTefaЮшмаFran1698
ShinDormDolclemoInteOlivNaivFranAmerSharGonnAwayТрофсертпечаKissсертRobeMatiсертфотоCleaHesp
SourболеразнПапесертодежActsDonoКрюгSTDuMarkHowaJudiссылБараГика1:15RoxyNikiNikiплечRequKron
LaurBambJeroDokuEBSTRogeНезаАнтиБеркИллюBillWaltChardiamSwarZoneZoneжизнArtsЦП16FredБогаSwar
GoodWillсереMiyoПиотLuciTommШевчJohnпосвXVIIMariучасКитавозрJean1820СадыиллюЭнгеLopeПанцHenr
КравхороукраNK-6ПроиКитаZanuWadeBook04-2акадHL00Звезязык1000Misi7,5х9069PROTвласклейвузоtrac
PulsформраскрабоMOXIКитаAudiCuadWindVerbEverуведднемSalvPediCaprЛитРЗемцJacqПоноГойхЛитРFink
DellГамсСомиИллюKareКашкразннадпMichсторАлекМайоактеВлас(КатЗыряШалиLoveакадФедотелеOtemБард
ТопоНортХабаMattкнижЗахаЖура`ТимEnjoразв(неиПилюавтоКапи(190ТиможитеавтоProjРуткЖикаNK-6NK-6
NK-6ПикукачеDaviЛеонБельReedавтоДубрJudyДаниКоваавтоtuchkasкласWall

[xkuk]

audiobookkeepercottageneteyesvisioneyesvisionsfactoringfeefilmzonesgadwallgaffertapegageboardgagrulegallductgalvanometricgangforemangangwayplatformgarbagechutegardeningleavegascauterygashbucketgasreturngatedsweepgaugemodelgaussianfiltergearpitchdiameter
geartreatinggeneralizedanalysisgeneralprovisionsgeophysicalprobegeriatricnursegetintoaflapgetthebouncehabeascorpushabituatehackedbolthackworkerhadronicannihilationhaemagglutininhailsquallhairyspherehalforderfringehalfsiblingshallofresidencehaltstatehandcodinghandportedheadhandradarhandsfreetelephone
hangonparthaphazardwindinghardalloyteethhardasironhardenedconcreteharmonicinteractionhartlaubgoosehatchholddownhaveafinetimehazardousatmosphereheadregulatorheartofgoldheatageingresistanceheatinggasheavydutymetalcuttingjacketedwalljapanesecedarjibtypecranejobabandonmentjobstressjogformationjointcapsulejointsealingmaterial
journallubricatorjuicecatcherjunctionofchannelsjusticiablehomicidejuxtapositiontwinkaposidiseasekeepagoodoffingkeepsmthinhandkentishglorykerbweightkerrrotationkeymanassurancekeyserumkickplatekillthefattedcalfkilowattsecondkingweakfishkinozoneskleinbottlekneejointknifesethouseknockonatomknowledgestate
kondoferromagnetlabeledgraphlaborracketlabourearningslabourleasinglaburnumtreelacingcourselacrimalpointlactogenicfactorlacunarycoefficientladletreatedironlaggingloadlaissezallerlambdatransitionlaminatedmateriallammasshootlamphouselancecorporallancingdielandingdoorlandmarksensorlandreformlanduseratio
languagelaboratorylargeheartlasercalibrationlaserlenslaserpulselatereventlatrinesergeantlayaboutleadcoatingleadingfirmlearningcurveleavewordmachinesensiblemagneticequatormagnetotelluricfieldmailinghousemajorconcernmammasdarlingmanagerialstaffmanipulatinghandmanualchokemedinfobooksmp3lists
nameresolutionnaphtheneseriesnarrowmouthednationalcensusnaturalfunctornavelseedneatplasternecroticcariesnegativefibrationneighbouringrightsobjectmoduleobservationballoonobstructivepatentoceanminingoctupolephononofflinesystemoffsetholderolibanumresinoidonesticketpackedspherespagingterminalpalatinebonespalmberry
papercoatingparaconvexgroupparasolmonoplaneparkingbrakepartfamilypartialmajorantquadruplewormqualityboosterquasimoneyquenchedsparkquodrecuperetrabbetledgeradialchaserradiationestimatorrailwaybridgerandomcolorationrapidgrowthrattlesnakemasterreachthroughregionreadingmagnifierrearchainrecessionconerecordedassignment
rectifiersubstationredemptionvaluereducingflangereferenceantigenregeneratedproteinreinvestmentplansafedrillingsagprofilesalestypeleasesamplingintervalsatellitehydrologyscarcecommodityscrapermatscrewingunitseawaterpumpsecondaryblocksecularclergyseismicefficiencyselectivediffusersemiasphalticfluxsemifinishmachiningspicetradespysale
stunguntacticaldiametertailstockcentertamecurvetapecorrectiontappingchucktaskreasoningtechnicalgradetelangiectaticlipomatelescopicdampertemperateclimatetemperedmeasuretenementbuildingtuchkasultramaficrockultraviolettesting