美老鼠壓力實驗 意外發現生髮物質
根據統計，全球一的男性和五分之二的女性碰到過度掉髮的困擾。
而美國洛杉磯加州大學的研究人員最近在對老鼠進行的壓力實驗當中意外發現一種壓力賀爾蒙阻斷劑能夠讓老鼠被剃掉的毛髮重新長回來。
科學家將進一步研究這種物質使用在人體會不會有同樣的效果。
美國加州大學洛杉磯分校的研究人員，在進行老鼠壓力的實驗過程中，意外的發現一種能讓毛髮重新生長的化合物。這個研究團隊原本要觀察的是，一種經過基因改良，能過量分泌促腎上腺皮質激素的老鼠，面臨壓力時牠們的腸胃系統功能如何運作。他們把老鼠背上的毛髮剃掉，就好像禿了一樣，結果發現了出人意料之外的發展。
這種壓力賀爾蒙阻斷劑，也被稱做為astressin-B，效果相當持久，沒多久被剃毛的老鼠毛髮全都長回來了，和其它的老鼠完全無法分辯。
接下來研究人員關心的就是，這用在人類的身上會不會也有同樣的效果。
(2011-03-28 20:00) 公視晚間新聞
==============
毛髮剃掉本來就會長回來吧? 怪怪的研究...
把人理光頭, 再每天給他喝水, 發現沒多久頭髮全長回來了, 所以水對生髮有效?
美老鼠壓力實驗 意外發現生髮物質
版主: 版主021
-
銀色大道
- V1
- 文章: 1184
- 註冊時間: 週二 5月 15, 2007 10:50 am
Re: 美老鼠壓力實驗 意外發現生髮物質
CRF Receptor Antagonist Astressin-B Reverses and Prevents Alopecia in CRF Over-Expressing Mice
http://www.plosone.org/article/info%3Ad ... ne.0016377
這"新聞"約1個月前
Corticotropin-releasing factor (CRF) signaling pathways are involved in the stress response, and there is growing evidence supporting hair growth inhibition of murine hair follicle in vivo upon stress exposure. We investigated whether the blockade of CRF receptors influences the development of hair loss in CRF over-expressing (OE)-mice that display phenotypes of Cushing's syndrome and chronic stress, including alopecia. The non-selective CRF receptors antagonist, astressin-B (5 µg/mouse) injected peripherally once a day for 5 days in 4–9 months old CRF-OE alopecic mice induced pigmentation and hair re-growth that was largely retained for over 4 months. In young CRF-OE mice, astressin-B prevented the development of alopecia that occurred in saline-treated mice. Histological examination indicated that alopecic CRF-OE mice had hair follicle atrophy and that astressin-B revived the hair follicle from the telogen to anagen phase. However, astressin-B did not show any effect on the elevated plasma corticosterone levels and the increased weights of adrenal glands and visceral fat in CRF-OE mice. The selective CRF2 receptor antagonist, astressin2-B had moderate effect on pigmentation, but not on hair re-growth. The commercial drug for alopecia, minoxidil only showed partial effect on hair re-growth. These data support the existence of a key molecular switching mechanism triggered by blocking peripheral CRF receptors with an antagonist to reset hair growth in a mouse model of alopecia associated with chronic stress.
http://www.plosone.org/article/info%3Ad ... ne.0016377
這"新聞"約1個月前
Corticotropin-releasing factor (CRF) signaling pathways are involved in the stress response, and there is growing evidence supporting hair growth inhibition of murine hair follicle in vivo upon stress exposure. We investigated whether the blockade of CRF receptors influences the development of hair loss in CRF over-expressing (OE)-mice that display phenotypes of Cushing's syndrome and chronic stress, including alopecia. The non-selective CRF receptors antagonist, astressin-B (5 µg/mouse) injected peripherally once a day for 5 days in 4–9 months old CRF-OE alopecic mice induced pigmentation and hair re-growth that was largely retained for over 4 months. In young CRF-OE mice, astressin-B prevented the development of alopecia that occurred in saline-treated mice. Histological examination indicated that alopecic CRF-OE mice had hair follicle atrophy and that astressin-B revived the hair follicle from the telogen to anagen phase. However, astressin-B did not show any effect on the elevated plasma corticosterone levels and the increased weights of adrenal glands and visceral fat in CRF-OE mice. The selective CRF2 receptor antagonist, astressin2-B had moderate effect on pigmentation, but not on hair re-growth. The commercial drug for alopecia, minoxidil only showed partial effect on hair re-growth. These data support the existence of a key molecular switching mechanism triggered by blocking peripheral CRF receptors with an antagonist to reset hair growth in a mouse model of alopecia associated with chronic stress.